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Research

Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active-controlled, phase 4, randomized trial

Hypertension is a risk factor for coronary heart disease and stroke, and is one of the leading causes of death. Although over a billion people are affected worldwide, only half of them receive adequate treatme...

Gyu Chul Oh, Hae-Young Lee, Wook Jin Chung, Ho-Joong Youn, Eun-Joo Cho, Ki-Chul Sung, Shung Chull Chae, Byung-Su Yoo, Chang Gyu Park, Soon Jun Hong, Young Kwon Kim, Taek-Jong Hong, Dong-Ju Choi, Min Su Hyun, Jong Won Ha, Young Jo Kim…

Clinical Hypertension 2017 23:18

Published on: 4 September 2017
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Research

Internal validation of an automated system for brachial and femoral flow mediated dilation

Flow Mediated Dilation (FMD) has immense potential to become a clinical, non-invasive biomarker of endothelial function and nitric oxide bioavailability, which regulate vasomotor activity. Unfortunately, FMD a...

Brycen Ratcliffe, Robert Pawlak, Francisco Morales, Caleb Harrison and Alvaro N. Gurovich

Clinical Hypertension 2017 23:17

Published on: 22 August 2017
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Research

A multicenter cohort study of primary hypertension in Korea: study design and interim analysis of the Korean registry of target organ damage in hypertension (KorHR)

The Korean Registry of Target Organ Damage in Hypertension aims to evaluate the clinical characteristics and prevalence of subclinical target organ damage in Korean hypertensive patients.

Suk-Won Choi, Seong Woo Han, Jong Sun Ok, Byung-Su Yoo, Mi-Seung Shin, Sung Ha Park and Kyu-Hyung Ryu

Clinical Hypertension 2017 23:16

Published on: 2 August 2017
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Research

Effect of respiratory pattern on automated clinical blood pressure measurement: an observational study with normotensive subjects

It has been reported that deep breathing could reduce blood pressures (BP) in general. It is also known that BP is decreased during inhalation and increased during exhalation. Therefore, the measured BPs could...

Natalia Herakova, Nnenna Harmony Nzeribe Nwobodo, Ying Wang, Fei Chen and Dingchang Zheng

Clinical Hypertension 2017 23:15

Published on: 18 July 2017
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Research

Determinants of uncontrolled hypertension among clients on anti-retroviral therapy in Kadoma City, Zimbabwe, 2016

Clients on anti-retroviral therapy (ART) are living longer and have risk of hypertension. Side effects of medicines and aging increase this risk. Hypertension prevalence among clients on ART in Kadoma City was...

Pamela Nyaradzai Magande, Daniel Chirundu, Notion Tafara Gombe, More Mungati and Mufuta Tshimanga

Clinical Hypertension 2017 23:14

Published on: 4 July 2017
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Review

Pathophysiology of copeptin in kidney disease and hypertension

Copeptin is derived from the cleavage of the precursor of arginine vasopressin (AVP), produced in an equimolar ratio in hypothalamus and processed during axonal transport AVP is an unstable peptide and has a s...

Baris Afsar

Clinical Hypertension 2017 23:13

Published on: 13 June 2017
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Letter to the Editor

Hypertensive response to exercise and exercise training in hypertension: odd couple no more

The diagnostic and prognostic implication of exaggerated blood pressure response to exercise has been controversial, with opinions ranging from a benign process to a harbinger of potential cardiovascular morbi...

Elisa Caldarone, Paolo Severi, Mario Lombardi, Stefania D’Emidio, Andrea Mazza, Maria Grazia Bendini and Massimo Leggio

Clinical Hypertension 2017 23:11

Published on: 2 June 2017
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Research

Attitudes and preferences for the clinical management of hypertension and hypertension-related cerebrovascular disease in the general practice: results of the Italian hypertension and brain survey

The aim of this survey was to evaluate attitudes and preferences for the clinical management of hypertension and hypertension-related cerebrovascular diseases (CVD) in Italy.

Giuliano Tocci, Arrigo F. Cicero, Massimo Salvetti, Maria Beatrice Musumeci, Andrea Ferrucci, Claudio Borghi and Massimo Volpe

Clinical Hypertension 2017 23:10

Published on: 15 May 2017
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Research

Systolic blood pressure but not electrocardiogram QRS duration is associated with heart rate variability (HRV): a cross-sectional study in rural Australian non-diabetics

A positive correlation between ECG derived QRS duration and heart rate variability (HRV) parameters had previously been reported in young healthy adults. We note this study used a narrow QRS duration range, an...

Yvonne Yin Leng Lee, Herbert F. Jelinek and Craig S. McLachlan

Clinical Hypertension 2017 23:9

Published on: 2 May 2017
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Research

Revised definition of predicted left ventricular mass using ambulatory blood pressure in healthy Korean adults

Left ventricular hypertrophy is influenced by both hemodynamic and non-hemodynamic factors. Ambulatory blood pressure is correlated with left ventricular hypertrophy. We established the influences of hemodynam...

Bae Keun Kim, Enshi Xu, Bo Youl Choi, Yonggu Lee, Soon Gil Kim, Yukio Yamori and Jinho Shin

Clinical Hypertension 2017 23:8

Published on: 16 April 2017
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Review

Carotid artery intima-media thickness and hypertensive heart disease: a short review

Sustained by its relative ease of assessment, carotid artery intima-media thickness (cIMT) has emerged as an important surrogate marker of target organ damage in hypertensive heart disease over the last three ...

Costan G. Magnussen

Clinical Hypertension 2017 23:7

Published on: 2 April 2017
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Research

Association of angiotensinogen gene SNPs and haplotypes with risk of hypertension in eastern Indian population

Angiotensinogen (AGT) enzyme comprises a vital module of RAAS system that effectively controls the blood pressure and related cardiovascular functions. Ample association studies have reported the importance of...

Pulakes Purkait, Kalpataru Halder, Sunil Thakur, Abhishikta Ghosh Roy, Pradip Raychaudhuri, Sandip Bhattacharya, B. N. Sarkar and J. M. Naidu

Clinical Hypertension 2017 23:12

Published on: 29 March 2017
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Research

Office orthostatic blood pressure measurements and ambulatory blood pressure monitoring in the prediction of autonomic dysfunction

In this retrospective analysis we investigated the predictive performance of orthostatic hypotension (OH) and ambulatory blood pressure monitoring (ABP) to predict autonomic dysfunction.

Kawther F. Alquadan, Girish Singhania, Abhilash Koratala and Abutaleb A. Ejaz

Clinical Hypertension 2017 23:3

Published on: 15 March 2017
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Research

The cardiovascular risk factors associated with the plaque pattern on coronary computed tomographic angiography in subjects for health check-up

Although it is known that coronary computed tomographic angiography (CCTA) offers highly negative predictive value to exclude obstructive coronary lesions, the plaque pattern on CCTA has not been fully underst...

Dong-Hyeon Lee, Ho-Joong Youn, Hae-Ok Jung, Kiyuk Chang, Yun-Seok Choi and Jung Im Jung

Clinical Hypertension 2017 23:6

Published on: 2 March 2017
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Research

Comparison of endothelial function improvement estimated with reactive hyperemia index between ramipril and telmisartan in hypertensive patients

Endothelium has a function to regulate vascular tone by releasing mediators either vasodilating or vasoconstricting blood vessels. Endothelial dysfunction can be measured conveniently by Reactive Hyperemia Ind...

You-Jeong Ki, Jae-Bin Seo, Hack-Lyoung Kim, Woo-Hyun Lim, Hye Yeon Seo, Jin Yong Lee and Woo-Young Chung

Clinical Hypertension 2017 23:4

Published on: 15 February 2017
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Research

Autonomic imbalance captures maternal and fetal circulatory response to pre-eclampsia

Pre-eclampsia (PE) is a gestational disease featured by hypertension, arterial systemic vasculopathy, multiple organ failure and fetal compromise.

Igor Lakhno

Clinical Hypertension 2017 23:5

Published on: 8 February 2017
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Research

Association between central blood pressure, arterial stiffness, and mild cognitive impairment

To determine the relationship between central blood pressure (CBP) indices and mild cognitive impairment (MCI) in adults over the age of 50.

R. Suleman, R. Padwal, P. Hamilton, A. Senthilselvan and K. Alagiakrishnan

Clinical Hypertension 2017 23:2

Published on: 15 January 2017
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Research

Effects of metabolic syndrome on aortic pulse wave velocity

The purpose of this study was to compare the value and evaluate the validity of non-invasive methods for the detection of vascular stiffness in never-treated individuals with metabolic syndrome (MetS).

Dong-Hyeon Lee, Ho-Joong Youn, Woo-Baek Chung, Yun-Seok Choi, Jong-Min Lee, Chul-Soo Park, Hae-Ok Jung, Hui-Kyung Jeon and Man-Young Lee

Clinical Hypertension 2017 23:1

Published on: 6 January 2017
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Research

Systolic blood pressure values might further risk-stratify the adverse outcomes of LVH in older patients with chronic kidney disease

LVH is highly prevalent in patients with CKD and is independently associated with subsequent cardiovascular events.

Carlos R. Franco Palacios, Pankaj Goyal, Amanda M. Thompson and Brent Deschaine

Clinical Hypertension 2016 22:21

Published on: 23 November 2016
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Review

Neuronal nitric oxide synthase in hypertension – an update

Hypertension is a prevalent condition worldwide and is the key risk factor for fatal cardiovascular complications, such as stroke, sudden cardiac death and heart failure. Reduced bioavailability of nitric oxid...

Yin Hua Zhang

Clinical Hypertension 2016 22:20

Published on: 3 November 2016
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Research

Relationship between retinopathy and renal abnormalities in black hypertensive patients

Complications of hypertension are particularly common in people of African descent but previous reports had suggested rarity of hypertensive retinopathy in black Africans. We evaluated retinal changes among Ni...

A. B. Omotoso, P. M. Kolo, T. O. Olanrewaju, J. F. Owoeye, S. A. Biliaminu and V. A. Olatunji

Clinical Hypertension 2016 22:19

Published on: 21 October 2016
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Research

The flavor and acceptability of six different potassium-enriched (sodium reduced) iodized salts: a single-blind, randomized, crossover design

Hypertension is a serious public health problem. Potassium-enriched salt is suggested as a tool for lowering blood pressure. However, its flavor and taste acceptability is essential for population-based salt r...

Akram Maleki, Ali Reza Soltanian, Fatemeh Zeraati, Vida Sheikh and Jalal Poorolajal

Clinical Hypertension 2016 22:18

Published on: 17 October 2016
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Review

Hypertensive response to exercise: mechanisms and clinical implication

A hypertensive response to exercise (HRE) is frequently observed in individuals without hypertension or other cardiovascular disease. However, mechanisms and clinical implication of HRE is not fully elucidated...

Darae Kim and Jong-Won Ha

Clinical Hypertension 2016 22:17

Published on: 26 July 2016
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Research

Prognostic value of systolic short-term blood pressure variability in systolic heart failure

Traditional cardiovascular risk factors in the general population are usually correlated to a better prognosis in patients with chronic heart failure (HF). Most of the studies show that blood pressure variabil...

Matthieu Berry, Olivier Lairez, Joelle Fourcade, Jérôme Roncalli, Didier Carrié, Atul Pathak, Bernard Chamontin and Michel Galinier

Clinical Hypertension 2016 22:16

Published on: 12 July 2016
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Review

Clinical assessment of hypertension in children

The use of blood pressure measurements have become a routine part of physical exam for the evacuation of cardiovascular health adults and, more recently, children. The most widely used definition of hypertensi...

Nisarg Patel and Nicole Walker

Clinical Hypertension 2016 22:15

Published on: 17 May 2016
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