Variables | Controls (n = 132) | Cases (n = 132) | P-values |
---|---|---|---|
Age (years)a | 45.9 ± 14.5 | 61.7 ± 11.7 | < 0.0001 |
Gender | |||
 Male | 24 (18.2) | 77 (58.3) | < 0.0001 |
 Female | 108 (81.8) | 55 (41.7) | < 0.0001 |
 Family history of CKD | 1 (0.8) | 15 (11.4) | < 0.0001 |
Anthropometric indicesa | |||
 BMI (Kg/m2) | 32.2 ± 9.4 | 35.3 ± 15.8 | 0.053 |
 SBP (mmHg) | 142.4 ± 22.6 | 167.2 ± 29.5 | < 0.0001 |
 DBP (mmHg) | 87.6 ± 13.4 | 97.4 ± 21.6 | < 0.0001 |
Biochemical analytes | |||
 Total cholesterol (mmol/L)a | 5.0 ± 1.1 | 4.5 ± 1.3 | 0.001 |
 Triglycerides (mmol/L)a | 1.39 ± 0.67 | 1.45 ± 0.71 | 0.455 |
 HDL-C (mmol/L)a | 1.62 ± 0.30 | 1.40 ± 0.46 | < 0.0001 |
 LDL-C (mmol/L)a | 2.73 ± 0.99 | 2.45 ± 1.15 | 0.035 |
 Glucose (mmol/L)a | 5.6 ± 1.21 | 5.5 ± 1.3 | 0.518 |
 Urea (mg/dl)a | 4.0 ± 1.1 | 19.0 ± 8.72 | < 0.0001 |
 Creatinine (mg/dl)b | 71.0 ± 13.0 | 889.1 ± 533.76 | < 0.0001 |
 Urinary protein (mg/dl)b | 210.0 (120.0–285.0) | 530.0 (360.0–760.0) | < 0.0001 |
 Urinary Albumin (mg/dl)b | 10.0 (10.0–20.0) | 110.0 (35.0–280.0) | < 0.0001 |
 Urinary Creatinine (mg/dl)b | 151.5 (72.6–223.3) | 163.6 (107.4–253.0) | 0.021 |
 uACR (μg/mg)b | 92.0 (65.9–172.0) | 729.1 (144.3–1783.3) | < 0.0001 |
 uPCR (mg/mg)b | 1.40 (0.90–2.10) | 3.05 (1.63–5.30) | < 0.0001 |
 Overweight/Obesity | 100 (75.8) | 125 (94.7) | < 0.0001 |
 Uncontrolled BP | 47 (35.6) | 81 (61.4) | < 0.0001 |
 Hyperglycaemia | 34 (25.8) | 42 (31.8) | 0.277 |
 Dyslipidaemia | 66 (50.0) | 70 (53.0) | 0.712 |
 Microalbuminuria (μg/mg) | 124 (93.9) | 31 (23.5) | < 0.0001 |
 Macroalbuminuria (μg/mg) | 6 (4.5) | 92 (69.7) | < 0.0001 |
rs3752462 | |||
 CC | 3 (2.3) | 3 (2.3) | 1.000 |
 CT | 42 (31.8) | 106 (80.3) | < 0.0001 |
 TT | 87 (65.9) | 23 (17.4) | < 0.0001 |
 MAF | 0.820 | 0.576 | < 0.0001 |