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Table 2 Meta-regression analyses (Dependent variable: natural log of relative risk for all-cause mortality)

From: Are the effects of blood pressure lowering treatment diminishing?: meta-regression analyses

  Model 1M (single) Model 2M (multiple)
Variable exp(b) 95% CI p-value exp(b) 95% CI p-value
Trial start year (per 10 years) 1.05 1.02–1.09 0.004 1.05 0.99–1.10 0.078
  Adjusted R2 = 34.8%    
Age (per 10 years) 1.01 0.96–1.07 0.633 0.97 0.91–1.03 0.311
  Adjusted R2 = −1.8%    
Sample size (per 1000 participants) 1.01 1.00–1.01 0.012 1.00 1.00–1.01 0.188
  Adjusted R2 = 32.7%    
Baseline SBP (per 10 mmHg) 0.99 0.97–1.01 0.414 1.02 0.99–1.05 0.201
  Adjusted R2 = −2.3%    
SBP difference (per 10 mmHg) 0.93 0.87–0.99 0.033 1.00 0.90–1.11 0.990
  Adjusted R2 = 28.3%    
Region (per category)
 Mixed region 1 (ref)    1 (ref)   
 North America 0.85 0.77–0.93 0.001 0.89 0.78–1.00 0.055
 Europe 0.93 0.85–1.00 0.062 0.95 0.85–1.06 0.341
 Asia 0.80 0.70–0.91 0.001 0.84 0.73–0.97 0.020
 Oceania 0.69 0.46–1.04 0.077    
 South Africa 0.98 0.06–16.9 0.988 0.94 0.05–16.3 0.968
  Adjusted R2 = 61.9%    
Adjusted R2   68.9%
K   74
  1. exp(b) the exponentiation of the b coefficient; ref. reference; CI confidence interval; K number of trials