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Table 2 Hazard ratios associated with ACR and age subgroup for all-cause mortality

From: Albumin-to-creatinine ratio as a predictor of all-cause mortality and hospitalization of congestive heart failure in Chinese elder hypertensive patients with high cardiovascular risks

Outcome and age subgroups

ACR category

≦10 mg/g

10 to 30 mg/g

> 30 mg/g

Total, n or P valuee

P for interactionf

All-cause mortality

 ≦65 years

  Events, n

30

5

3

38

 

  Patients, n

579

92

76

747

 

  Hazard ratio (95% CI)

   Unadjusted

1(ref)

1.05 (0.41–2.70)

0.76 (0.23–2.50)

0.896

 

   Adjusted by model 1a

1(ref)

0.49 (0.11–2.13)

0.96 (0.27–3.38)

0.637

 

   Adjusted by model 2b

1(ref)

0.48 (0.11–2.10)

0.95 (0.27–3.42)

0.624

 

  > 65 years

  Events, n

55

6

18

79

 

  Patients, n

531

104

92

727

 

  Hazard ratio (95% CI)

   Unadjusted

1(ref)

0.55 (0.24–1.29)

2.00 (1.18–3.41)

0.008

 

   Adjusted by model 1a

1(ref)

0.55 (0.19–1.57)

1.86 (0.94–3.67)

0.061

 

   Adjusted by model 2b

1(ref)

0.56 (0.19–1.61)

1.95 (0.99–3.86)

0.048

 

 Total

  Events, n

85

11

21

117

 

  Patients, n

1110

196

168

1474

 

  Hazard ratio (95% CI)

   Unadjusted

1(ref)

0.73 (0.39–1.38)

1.69 (1.05–2.72)

0.043

0.180f

   Adjusted by model 3c

1(ref)

0.50 (0.21–1.20)

1.45 (0.81–2.60)

0.088

0.594f

   Adjusted by model 4d

1(ref)

0.51 (0.21–1.20)

1.47 (0.82–2.65)

0.082

0.524f

  1. ACR indicates albuminuria-to-creatinine ratio
  2. amodel 1 was adjusted for sex, heart rates, systolic blood pressure, diabetes, prior myocardial infarction, stroke/transient ischemic attack, snoring, alcohol consumption, smoking, physical activity
  3. bmodel 2 was adjusted for sex, heart rates, systolic blood pressure, diastolic blood pressure, diabetes, prior myocardial infarction, stroke/transient ischemic attack, eGFR, statin, diuretics, angiotensin converting enzyme inhibitor or angiotensin II receptor antagonist, snoring, alcohol consumption, smoking, physical activity
  4. cmodel 3 was adjusted model 1 plus age. dmodel 4 was adjusted model 2 plus age
  5. eP indicates the comparison between different ACR categories
  6. fP for interaction indicates the interaction between ACR categories and age subgroups
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Clinical Hypertension

ISSN: 2056-5909

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