Goldner’s trichrome stained section and collagen area fraction. (A) Goldner’s trichrome-stained section (×400) in C group, AD group, CA group, and AD + CA group. (B) Collagen area fraction within the aorta in each group. C, control; AD, adriamycin-treated; CA, candesartan-treated; AD + CA, adriamycin + candesartan-treated. p values were corrected by Dunnett method.