Fig. 1From: Therapeutic roles of thiazides and loop diuretics in blood pressure control and renal protection against chronic kidney diseaseSchematic view of volume overload-induced hypertension in chronic kidney disease. Reduced glomerular filtration rate in chronic kidney disease eventually produces sodium retention and a fall in plasma renin level with minimal dependence of systemic angiotensin II, causing volume expansion and subsequent increased arterial pressure. In this situation, blockades of renin-angiotensin system are less effective in controlling systemic blood pressureBack to article page