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Table 5 Hazard ratios and 95% confidence intervals for all-cause mortality according to quintiles of baseline serum uric acid to creatinine (n = 2,017)

From: Serum uric acid to creatinine ratio is a useful predictor of all-cause mortality among hypertensive patients

Baseline characteristic

No. of participants

Quintiles of baseline SUA/Cr

Multivariable-adjusted hazard ratio (95% confidence interval)

P for trend

First

Second

Third

Fourth

Fifth

Age (yr)

       

 < 65

586

2.22 (0.89–5.56)

1.00

2.16 (0.88–5.34)

1.76 (0.72–4.26)

3.27 (1.35–7.88)

0.093

 ≥ 65

1,431

1.02 (0.79–1.32)

1.00

1.14 (0.87–1.49)

1.43 (1.08–1.90)

1.48 (1.09–2.01)

0.030

Body mass index (kg/m2)

 < 22.0

559

0.82 (0.55–1.23)

1.00

0.89 (0.56–1.41)

1.33 (0.82–2.14)

1.62 (0.99–2.67)

0.045

 ≥ 22.0

1,458

1.35 (0.98–1.86)

1.00

1.35 (0.98–1.85)

1.58 (1.13–2.19)

1.64 (1.15–2.34)

0.053

Chronic kidney disease

 eGFR < 60 mL/min/1.73 m2/yr

275

1.84 (1.10–3.08)

1.00

2.00 (1.10–3.61)

0.96 (0.42–2.20)

6.18 (2.27–16.8)

0.002

 eGFR ≥ 60 mL/min/1.73 m2/yr

1,742

0.87 (0.64–1.17)

1.00

1.08 (0.81–1.44)

1.36 (1.02–1.82)

1.39 (1.02–1.88)

0.013

Serum uric acid lowering medication

 No

1,896

1.07 (0.83–1.38)

1.00

1.20 (0.92–1.57)

1.47 (1.11–1.95)

1.58 (1.17–2.14)

0.011

 Yes

121

1.68 (0.48–5.92)

1.00

1.56 (0.47–5.21)

1.28 (0.44–3.78)

2.30 (0.69–7.70)

0.670

Time to death (day)

 < 1,095

50

-

-

-

-

-

-

 ≥ 1,095

1,967

1.11 (0.85–1.43)

1.00

1.18 (0.90–1.54)

1.42 (1.08–1.88)

1.57 (1.16–2.12)

0.025

  1. Adjusted for baseline of all confounding factors in Table 2. The quintiles are distributed as the following: the first quintile, < 5.89; the second, 5.89–6.99; the third, 7.00–7.87; the fourth, 7.88–9.00; and the fifth, ≥ 9.01
  2. SUA/Cr Serum uric acid to creatinine, eGFR Estimated glomerular filtration rate