Table 1 Association studies of known SNPs of VDR gene with chronic disease
Study | Year | Country | Type of study | SNP | Disease | Outcome |
|---|---|---|---|---|---|---|
Liu et al. [34] | 2021 | China | Meta-analysis | Bsm I, Apa I, Taq I, Fok I | GDM | Taq I and Apa I associated with risk of GDM. No association found between Bsm I and Taq I with the risk of GDM. |
Tizaoui et al. [35] | 2015 | Tunisia | Meta-analysis (PRISMA) | Taq I, Bsm I, Fok I | RA | Taq I and Fok I VDR polymorphisms significantly associated with RA risk. Bsm I, marginal association seen with RA. |
Magiełda-Stola et al. [36] | 2021 | Poland | Case control | Bsm I, Apa I, Fok I, Taq I | Preeclampsia | Bsm I is significantly found more frequent in preeclamptic women. Taq I/Apa I/Bsm I was significantly associated with higher systolic and diastolic blood pressure. Bsm I polymorphism is closely associated with a higher predisposition to hypertension. |
Nam et al. [37] | 2021 | Republic of Korea | Cross sectional | Bsm I, Apa I | Obesity DM | Bsm I and Apa I were highly associated with obesity. Both SNPs were not associated with DM. |
Abouzid et al. [38] | 2021 | Poland | Preliminary | Bsm I, Apa I, Fok I, Taq I | CVD | Apa I, Tag I, and Bsm I was found to be associated with an increased risk of obesity. Fok I was associated with a higher incidence of heart failure and hypertension. Bsm I was found to be associated with lower risk of CVD. |
Eweida et al. [39] | 2021 | Egypt | Case control | Bsm I, Fok I | CVD | Both SNPs are associated with risk of CVD in Egyptian patients with or without diabetes. |
Caccamo et al. [40] | 2020 | Italy | Case control | Fok I, Bsm I | GH | Significant association was found between Fok I and Bsm I with GH. |
Aristizabal-Pachon et al. [41] | 2022 | Colombia | Case control | Fok I, Taq I | Melanoma cancer | Fok I polymorphism was associated with melonma cancer risk. Taq I polymorphism was associated with a protective effect against this cancer. |