Fig. 2

Proposed mechanism for action of vitamin D on renin expression. 1,25(OH)₂D₃, 1,25-dihydroxyvitamin D; Gα_s, G_s protein α subunit; AC, adenylate cyclase; cAMP, cyclic adenosine monophosphate; VDR, vitamin D receptor; PKA, protein kinase A; P, phosphate; CREB, cyclic adenosine monophosphate dependent response element binding protein; CRE, cyclic adenosine monophosphate response element; CBP, cyclic adenosine monophosphate binding protein; Pol, polymerase. Created with BioRender (Toronto, Canada; https://biorender.com/). Adapted from Legarth et al. [12] according to the Creative Commons Attribution License