Validation of age- and sex-dependent association of uric acid and incident hypertension in rural areas

Clinical Hypertension

Table 3 Relative risk of hypertension according to uric acid level by sex and age

Group	UA	40-64 years					Over 65 years
		Incidence case	Crude		Adjusted^a)		Incidence case	Crude		Adjusted^a)
		Incidence case	HR (95% CI)	P-value	HR (95% CI)	P-value	Incidence case	HR (95% CI)	P-value	HR (95% CI)	P-value
Male	T1	23 (8.0)	1.00 (Reference)		1.00 (Reference)		32 (11.6)	1.00 (Reference)		1.00 (Reference)
	T2	30 (9.4)	1.17 (0.68–2.02)	0.56	0.95 (0.49–1.85)	0.88	34 (14.7)	1.27 (0.79–2.06)	0.33	1.14 (0.63–2.07)	0.66
	T3	50 (13.9)	1.74 (1.06–2.85)	<0.05	1.74 (0.92–3.28)	0.09	50 (19.2)	1.66 (1.07–2.59)	0.02	1.51 (0.87–2.63)	0.14
Female	T1	41 (7.1)	1.00 (Reference)		1.00 (Reference)		52 (17.6)	1.00 (Reference)		1.00 (Reference)
	T2	72 (9.9)	1.40 (0.95–2.05)	<0.05	1.22 (0.78–1.93)	0.38	43 (15.8)	0.89 (0.60–1.34)	0.59	0.91 (0.59–1.42)	0.68
	T3	88 (13.4)	1.88 (1.30–2.72)	<0.05	1.59 (1.01–2.50)	<0.05	64 (19.4)	1.10 (0.76–1.59)	0.61	0.94 (0.60–1.46)	0.77

UA uric acid, HR hazard ratio, CI confidence interval
Tertiles 1, 2, and 3, respectively, were defined as < 5.0, 5.0–6.0, and ≥ 6.0 mg/dL for men, and as < 3.8, 3.8–4.6, and ≥ 4.6 mg/dL for women
Incidences are presented as frequency (percentage)
^a)adjusted for age, baseline systolic and diastolic blood pressure, diabetes, dyslipidemia, body mass index, estimated glomerular filtration rate, drinking status, and smoking status

ISSN: 2056-5909