Table 2 Factors related to tolerability in intensive blood pressure control
| Factor | Clinical features |
|---|---|
| Functional status or physical fitness | Frailty, disability |
| Symptomatic aspects | Weakness, dizziness, fatigue |
| Diagnostic aspects |
Standardized office blood pressure measurement Exclusion of orthostatic hypotension: orthostatic blood pressure measurement Assessment of white-coat effect or masked effect Application of home or ambulatory blood pressure monitoring |
| Hemodynamic aspects |
Orthostatic hypotension Volume depletion or poor oral intake Presence of vascular stenosis in coronary, renal, and/or cerebral arteries |
| Related clinical event history |
Injurious fall Acute kidney injury Electrolytes abnormalities |
| Speed of up-titration |
Large pulse pressure Frail patients |