Table 2 Factors related to tolerability in intensive blood pressure control
Factor | Clinical features |
|---|---|
Functional status or physical fitness | Frailty, disability |
Symptomatic aspects | Weakness, dizziness, fatigue |
Diagnostic aspects | Standardized office blood pressure measurement Exclusion of orthostatic hypotension: orthostatic blood pressure measurement Assessment of white-coat effect or masked effect Application of home or ambulatory blood pressure monitoring |
Hemodynamic aspects | Orthostatic hypotension Volume depletion or poor oral intake Presence of vascular stenosis in coronary, renal, and/or cerebral arteries |
Related clinical event history | Injurious fall Acute kidney injury Electrolytes abnormalities |
Speed of up-titration | Large pulse pressure Frail patients |