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Table 2 Factors related to tolerability in intensive blood pressure control

From: A clinical algorithm to determine target blood pressure in the elderly: evidence and limitations from a clinical perspective


Clinical features

Functional status or physical fitness

Frailty, disability

Symptomatic aspects

Weakness, dizziness, fatigue

Diagnostic aspects

Standardized office blood pressure measurement

Exclusion of orthostatic hypotension: orthostatic blood pressure measurement

Assessment of white-coat effect or masked effect

Application of home or ambulatory blood pressure monitoring

Hemodynamic aspects

Orthostatic hypotension

Volume depletion or poor oral intake

Presence of vascular stenosis in coronary, renal, and/or cerebral arteries

Related clinical event history

Injurious fall

Acute kidney injury

Electrolytes abnormalities

Speed of up-titration

Large pulse pressure

Frail patients