Table 3 Comparisons of sensitivity, specificity, agreement and predictive values of hypercholesterolaemia at increasing diagnostic thresholds
Variable | TC ≥5.5 mmol/L, LDL-C ≥3.5 mmol/L and/or lipid-lowering medications | TC ≥6.2 mmol/L, LDL-C ≥4.1 mmol/L and/or lipid-lowering medications | TC ≥6.5 mmol/L, LDL-C ≥4.9 mmol/L and/or lipid-lowering medications | ||||||
|---|---|---|---|---|---|---|---|---|---|
OBJ+ | OBJ– | Total | OBJ+ | OBJ– | Total | OBJ+ | OBJ– | Total | |
SR+ | 1,362 | 122 | 1,484 | 1,201 | 283 | 1,484 | 1,073 | 411 | 1,484 |
SR– | 2,078 | 1,314 | 3,392 | 986 | 2,406 | 3,392 | 584 | 2,808 | 3,392 |
Total | 3,440 | 1,436 | 4,876 | 2,187 | 2,689 | 4,876 | 1,657 | 3,219 | 4,876 |
Prevalence OBJ+ (%) | 70.5 (69.3, 71.8) | 44.9 (43.5, 46.2) | 34.0 (32.7, 35.3) | ||||||
Prevalence SR+ (%) | 30.4 (29.1, 31.7) | 30.4 (29.1, 31.7) | 30.4 (29.1, 31.7) | ||||||
Sensitivity (%) | 39.6 (38.0, 41.2) | 54.9 (52.8, 57.0) | 64.8 (62.5, 67.1) | ||||||
Specificity (%) | 91.5 (90.1, 92.9) | 89.5 (88.3, 90.6) | 87.2 (86.1, 88.4) | ||||||
PPV (%) | 91.8 (90.4, 93.2) | 80.9 (78.9, 82.9) | 72.3 (70.0, 74.6) | ||||||
NPV (%) | 38.7 (37.1, 40.4) | 70.9 (69.4, 72.5) | 82.8 (81.5, 84.1) | ||||||
Kappa (κ) | 0.223 (0.205, 0.241) | 0.458 (0.435, 0.482) | 0.533 (0.508, 0.558) | ||||||