Table 2 Changes in 24-h ABPM: efficacy outcomes
|  | Telmisartan40/S-Amlodipine2.5 (n = 96) | Telmisartan80 (n = 88) | P-valuea) |
|---|---|---|---|
24 h mean SBP (mmHg) |  |  |  |
 Baseline | 132.6 ± 14.0 | 130.3 ± 13.8 |  |
 Week 8 | 122.5 ± 11.8 | 127.4 ± 15.6 |  |
 Change | −10.3 ± 11.5 | −3.0 ± 14.1 | < 0.001 |
24 h mean DBP (mmHg) | |||
 Baseline | 78.0 ± 10.6 | 78.5 ± 11.0 |  |
 Week 8 | 71.8 ± 8.1 | 76.8 ± 11.8 |  |
 Change | −6.2 ± 5.7 | −1.8 ± 8.0 | < 0.001 |
Nighttime mean SBP (mmHg) | |||
 Baseline | 128.5 ± 15.9 | 123.1 ± 14.7 |  |
 Week 8 | 115.4 ± 11.2 | 120.7 ± 18.0 |  |
 Change | −10.1 ± 14.7 | −2.8 ± 17.1 | 0.003 |
Nighttime mean DBP (mmHg) | |||
 Baseline | 72.7 ± 10.8 | 73.3 ± 11.0 |  |
 Week 8 | 67.4 ± 8.1 | 72.0 ± 13.2 |  |
 Change | −5.2 ± 7.8 | −1.4 ± 11.3 | 0.010 |
Mean daytime (06:00 ~ 21:59) SBP (mmHg) | |||
 Baseline | 135.3 ± 14.7 | 132.8 ± 14.4 |  |
 Week 8 | 125.1 ± 13.1 | 130.2 ± 15.6 |  |
 Change | −10.5 ± 11.9 | −2.6 ± 14.2 | < 0.001 |
Mean daytime DBP (06:00 ~ 21:59) (mmHg) | |||
 Baseline | 79.9 ± 11.1 | 80.3 ± 11.7 |  |
 Week 8 | 73.4 ± 8.8 | 78.8 ± 11.9 |  |
 Change | −6.6 ± 6.0 | −1.6 ± 8.0 | < 0.001 |
Mean morning-time (06:00 ~ 11:59) SBP (mmHg) | |||
 Baseline | 134.7 ± 13.6 | 133.6 ± 14.4 |  |
 Week 8 | 126.7 ± 14.1 | 130.7 ± 15.1 |  |
 Change | −8.4 ± 12.8 | −3.1 ± 14.2 | 0.009 |
Mean morning-time (06:00 ~ 11:59) DBP (mmHg) | |||
 Baseline | 80.6 ± 9.9 | 81.0 ± 11.1 |  |
 Week 8 | 74.7 ± 9.4 | 79.2 ± 11.5 |  |
 Change | −6.0 ± 7.7 | −1.8 ± 8.7 | < 0.001 |
Mean office SBP (mmHg) | |||
 Baseline | 154.8 ± 16.0 | 151.2 ± 14.9 |  |
 Week 8 | 139.4 ± 16.7 | 145.3 ± 16.0 |  |
 Change | −15.4 ± 15.3 | −5.9 ± 14.1 | < 0.001 |
Mean office DBP (mmHg) | |||
 Baseline | 88.9 ± 12.5 | 89.6 ± 11.4 |  |
 Week 8 | 81.2 ± 11.13 | 88.0 ± 1.8 |  |
 Change | −7.7 ± 9.1 | −1.6 ± 8.9 | < 0.001 |