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Table 3 Average daily dose and total dose of nebivolol in the safety population in BENEFIT-Korea study

From: Efficacy and safety of nebivolol in Korean patients with hypertension by age and sex: a subanalysis from the BENEFIT-KOREA study

Dose (mg) Male (n = 1871) Female (n = 1269) Total (n = 3140) P-value
Average daily dose of nebivolol 4.5 ± 0.99 4.4 ± 1.1 4.5 ± 1.0  
Total dose of nebivolol 792.1 ± 269.4 747.3 ± 290.1 774.0 ± 278.7 < 0.001a
Total dose of nebivolol by age (yr)
  < 50 818.5 ± 258.8 0.44b
 50–69 800.9 ± 270.8 < 0.001c
  ≥ 70 721.6 ± 288.6 < 0.001d
Average daily dose of nebivolol by age (yr)
  < 50 4.8 ± 0.6  
 50–69 4.6 ± 1.0  
  ≥ 70 4.2 ± 1.2  
  1. Values are presented as mean ± standard deviation. Average daily dose of nebivolol = total dose of nebivolol / total treatment period; total dose of nebivolol = total dose of nebivolol X treatment period
  2. aWilcoxon rank sum test; comparison between males and females. bWilcoxon rank sum test, comparison between < 50 years and 50–69 years. cWilcoxon rank sum test; comparison between 50 and 69 years and ≥ 70 years. dWilcoxon rank sum test; comparison between < 50 years and ≥ 70 years