| |
Observational analysis
|
Mendelian randomization Analysis
|
|---|
| |
Counted GRS
|
Weighted GRS
|
|---|
| |
OR (95% CI)
|
OR (95% CI)
|
OR (95% CI)
|
|---|
|
Men
|
|
Model 1
|
|
Optimal
|
1.00 (reference)
|
1.00 (reference)
|
1.00 (reference)
|
|
Near optimal
|
0.84 (0.75–0.95)
|
1.15 (0.97–1.37)
|
1.16 (0.97–1.37)
|
|
High
|
0.90 (0.79–1.01)
|
1.64 (1.25–2.16)
|
1.65 (1.26–2.17)
|
|
Model 2
|
|
Optimal
|
1.00 (reference)
|
1.00 (reference)
|
1.00 (reference)
|
|
Near optimal
|
0.91 (0.79–1.04)
|
1.07 (0.90–1.26)
|
1.07 (0.90–1.27)
|
|
High
|
1.02 (0.89–1.17)
|
1.40 (1.07–1.83)
|
1.41 (1.08–1.84)
|
|
Model 3
|
|
Optimal
|
1.00 (reference)
|
1.00 (reference)
|
1.00 (reference)
|
|
Near optimal
|
0.92 (0.80–1.05)
|
1.07 (0.90–1.27)
|
1.08 (0.91–1.27)
|
|
High
|
1.03 (0.90–1.18)
|
1.41 (1.08–1.84)
|
1.42 (1.09–1.85)
|
|
Women
|
|
Model 1
|
|
Optimal
|
1.00 (reference)
|
1.00 (reference)
|
1.00 (reference)
|
|
Near optimal
|
0.89 (0.79–0.99)
|
1.18 (1.03–1.35)
|
1.18 (1.03–1.36)
|
|
High
|
0.89 (0.80–0.99)
|
1.83 (1.51–2.23)
|
1.83 (1.50–2.23)
|
|
Model 2
|
|
Optimal
|
1.00 (reference)
|
1.00 (reference)
|
1.00 (reference)
|
|
Near optimal
|
0.90 (0.79–1.02)
|
1.18 (1.03–1.35)
|
1.18 (1.03–1.36)
|
|
High
|
0.92 (0.81–1.04)
|
1.83 (1.51–2.23)
|
1.83 (1.50–2.23)
|
|
Model 3
|
|
Optimal
|
1.00 (reference)
|
1.00 (reference)
|
1.00 (reference)
|
|
Near optimal
|
0.90 (0.79–1.02)
|
1.18 (1.03–1.35)
|
1.18 (1.03–1.35)
|
|
High
|
0.92 (0.81–1.03)
|
1.83 (1.50–2.23)
|
1.84 (1.51–2.24)
|
- Model 1: adjusted for age and body mass index
- Model 2: Model 1 + smoking and drinking status
- Model 3: Model 2 + salt intake
- LDL-C Low-density lipoprotein cholesterol, GRS Genetic risk score, OR Odds ratio
