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Table 4 Association between APOE (rs7412) genotype and potential confounders

From: Inference of a causal relation between low-density lipoprotein cholesterol and hypertension using mendelian randomization analysis

Variables Wild type
(N = 17,153)
Heterozygous
(N = 2316)
Homozygous
(N = 67)
p-value
Sex
 Men 6373 (37.2) 853 (86.8) 27 (40.3) 0.8265
 Women 10,780 (62.8) 1463 (63.2) 40 (59.7)  
Age 58.8 ± 9.6 58.6 ± 9.4 57.4 ± 10.3 0.4425
Family history of hypertension 3557 (20.9) 473 (20.6) 11 (16.4) 0.6169
Smoking status     0.7190
 Never smoker 9695 (70.9) 1300 (71.6) 39 (66.1)  
 Ex-smoker 2011 (14.7) 259 (14.3) 8 (13.6)  
 Current smoker 1970 (14.4) 257 (14.2) 12 (20.3)  
Alcohol Drinking     0.8591
 Never drinking 8923 (52.1) 1224 (52.9) 35 (52.2)  
 Ex-drinking 1247 (7.3) 157 (6.8) 6 (9.0)  
 Current drinking 6943 (40.6) 931 (40.3) 26 (38.8)  
Exercise     0.7963
  < 3 times per weeks 1231 (21.6) 156 (20.6) 5 (19.2)  
  ≥ 3 times per weeks 4479 (78.4) 602 (79.4) 21 (80.8)  
Systolic blood pressure (mmHg) 125.6 ± 17.9 124.7 ± 17.5 124.2 ± 17.8 0.0912
Diastolic blood pressure (mmHg) 78.9 ± 11.1 78.6 ± 10.9 78.7 ± 10.1 0.5107
Body mass index (kg/m2) 24.4 ± 3.2 24.4 ± 3.2 24.0 ± 2.8 0.6311
Waist circumference (cm) 83.9 ± 8.8 84.0 ± 8.9 82.8 ± 8.7 0.5142
HDL-C (mg/dL) 45.2 ± 10.9 46.4 ± 12.2 46.3 ± 12.2 <.0001
LDL-C (mg/dL) 127.2 ± 32.3 110.2 ± 28.9 99.2 ± 44.8 <.0001
Total cholesterol (mg/dL) 199.6 ± 35.7 184.9 ± 33.2 176.4 ± 56.0 <.0001
Triglyceride (mg/dL) 136.1 ± 68.4 141.4 ± 72.0 154.8 ± 82.1 0.0002
Salt intake (mg) 2507.4 ± 1541.7 2499.0 ± 1482.4 2167.4 ± 1075.6 0.1897
  1. Values are presented as a number (percentage) or mean ± standard deviation
  2. SBP Systolic blood pressure, DBP Diastolic blood pressure, BMI Body mass index, HDL-C High-density lipoprotein cholesterol, LDL-C Low-density lipoprotein cholesterol