Table 4 Association between APOE (rs7412) genotype and potential confounders
Variables | Wild type (N = 17,153) | Heterozygous (N = 2316) | Homozygous (N = 67) | p-value |
|---|---|---|---|---|
Sex | ||||
Men | 6373 (37.2) | 853 (86.8) | 27 (40.3) | 0.8265 |
Women | 10,780 (62.8) | 1463 (63.2) | 40 (59.7) | |
Age | 58.8 ± 9.6 | 58.6 ± 9.4 | 57.4 ± 10.3 | 0.4425 |
Family history of hypertension | 3557 (20.9) | 473 (20.6) | 11 (16.4) | 0.6169 |
Smoking status | 0.7190 | |||
Never smoker | 9695 (70.9) | 1300 (71.6) | 39 (66.1) | |
Ex-smoker | 2011 (14.7) | 259 (14.3) | 8 (13.6) | |
Current smoker | 1970 (14.4) | 257 (14.2) | 12 (20.3) | |
Alcohol Drinking | 0.8591 | |||
Never drinking | 8923 (52.1) | 1224 (52.9) | 35 (52.2) | |
Ex-drinking | 1247 (7.3) | 157 (6.8) | 6 (9.0) | |
Current drinking | 6943 (40.6) | 931 (40.3) | 26 (38.8) | |
Exercise | 0.7963 | |||
< 3 times per weeks | 1231 (21.6) | 156 (20.6) | 5 (19.2) | |
≥ 3 times per weeks | 4479 (78.4) | 602 (79.4) | 21 (80.8) | |
Systolic blood pressure (mmHg) | 125.6 ± 17.9 | 124.7 ± 17.5 | 124.2 ± 17.8 | 0.0912 |
Diastolic blood pressure (mmHg) | 78.9 ± 11.1 | 78.6 ± 10.9 | 78.7 ± 10.1 | 0.5107 |
Body mass index (kg/m2) | 24.4 ± 3.2 | 24.4 ± 3.2 | 24.0 ± 2.8 | 0.6311 |
Waist circumference (cm) | 83.9 ± 8.8 | 84.0 ± 8.9 | 82.8 ± 8.7 | 0.5142 |
HDL-C (mg/dL) | 45.2 ± 10.9 | 46.4 ± 12.2 | 46.3 ± 12.2 | <.0001 |
LDL-C (mg/dL) | 127.2 ± 32.3 | 110.2 ± 28.9 | 99.2 ± 44.8 | <.0001 |
Total cholesterol (mg/dL) | 199.6 ± 35.7 | 184.9 ± 33.2 | 176.4 ± 56.0 | <.0001 |
Triglyceride (mg/dL) | 136.1 ± 68.4 | 141.4 ± 72.0 | 154.8 ± 82.1 | 0.0002 |
Salt intake (mg) | 2507.4 ± 1541.7 | 2499.0 ± 1482.4 | 2167.4 ± 1075.6 | 0.1897 |