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Fig. 2 | Clinical Hypertension

Fig. 2

From: Prevalence of CYP17A1 gene mutations in 17α-hydroxylase deficiency in the Chinese Han population

Fig. 2

The CYP17A1 protein active center before (a) and after (b) amino acid changes. The CYP17A1 protein 3D model was mimicked by a computer. a Normal protein active center of 3D structure. The Van der Waals force between Tyr329 and Leu460 stabilized the protein active center. The region highlighted in orange was the missing part after mutation. b Mutated protein active center of 3D structure. The replacement of Tyr329 by Lys329 caused the loss of protein active center stability

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