Table 1 Study objectives of the cohort

1. To build a robust IPAH and HPAH patient registry through collaborative network across South Korea with 16 regional hospitals across the country.

2. To perform a long-term follow up of registered patients to characterize the clinical course of IPAH and HPAH patients among South Koreans.

3. To collect biospecimens of enrolled patients and to build a biobank for Korean PAH and HPAH.

4. To identify novel genetic mutations via next generation sequencing of the collected biospecimens.

5. To deep-phenotype PAH and HPAH through a detailed omics-level study from a large collection of patient samples.