Skip to main content

Advertisement

Table 2 IC50 [μM] values for PCI34051

From: Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice

Compound HDAC1 HDAC2 HDAC3 HDAC8
PCI34051 1.22 > 10 > 10 0.02
  1. The in vitro inhibitory activity of PCI34051 against each HDAC isoform was determined using the HDAC Fluorogenic Assay Kit from BPS Bioscience. The IC50 values were determined using 0.0001, 0.0003, 0.01, 0.03, 0.1, 0.3, 1, and 3 μM of the inhibitor.