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Fig. 2 | Clinical Hypertension

Fig. 2

From: Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice

Fig. 2

PCI34051 decreases vascular hypertrophy and expression of cell growth-related genes in Ang II-infused mice. a Representative images of H&E-stained aorta sections. Scale bar = 50 μm. b Aortic wall thickness was measured using NIS Elements Software (n = 8 per group). *** P < 0.001 versus sham group; ### P < 0.001 versus Ang II-infused group. E2F3 (c) and GATA6 (d) mRNA expression levels were normalized to GAPDH and relative amounts were calculated. Data are presented as mean ± SEM (n = 8 per group). * P < 0.05 and ** P < 0.01 versus sham-treated group; # P < 0.05 versus Ang II-infused group

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