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Fig. 1 | Clinical Hypertension

Fig. 1

From: Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice

Fig. 1

PCI34051 decreases blood pressure and AT1 mRNA expression in Ang II-infused mice. a Representative western blot images of HDAC8. VSMCs were treated with vehicle or PCI34051 at different concentrations for 24 h. b HDAC8 protein was quantified using densitometry. * P < 0.05 versus vehicle-treated VSMCs. c Systolic blood pressures in the experimental groups at 14th day after Ang II infusion. *** P < 0.001 versus sham group; ## P< 0.01 versus Ang II-infused group. d and e Aortic AT1 (d) and ACE1 (e) mRNA expression levels were normalized to GAPDH and relative amounts were calculated. Data are presented as mean ± SEM (n = 8 per group). *** P < 0.001 versus sham-treated group; # P < 0.05 versus Ang II-infused group; NS indicates not significant

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