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Table 4 Predictors of poor adherence to antihypertensive medications among hypertensive patients attending UOGCSH (N = 249)

From: Adverse effects and non-adherence to antihypertensive medications in University of Gondar Comprehensive Specialized Hospital

Variables Crude odds ratio (COR) (95% CI) p-value AOR (95% CI) p-value
Age
 Years 1.025 (1.000–1.050) 0.048 0.994 (0.959–1.030) 0.738
Duration of antihypertensive medication use
 Years 1.122 (1.056–1.193) 0.000 1.080 (0.996–1.170) 0.062
Number of antihypertensive medications used 1.478 (0.976–2.239) 0.065 1.496 (0.804–2.784) 0.204
Hydrochlorothiazide 0.659 (0.392–1.109) 0.116 0.837 (0.404–1.732) 0.632
Nifedipine 2.865 (1.502–5.465) 0.001 2.389 (0.900–6.340) 0.080
Other medications
 Yes 1.870 (1.090–3.207) 0.023 2.633 (0.598–11.587) 0.200
Number of other medications 1.262 (0.949–1.678) 0.109 0.876 (0.401–1.917) 0.741
Tiredness
 Yes 3.122 (1.825–5.348) 0.000 3.802 (1.723–8.391) 0.001
Sweats
 Yes 2.055 (1.023–4.128) 0.043 0.790 (0.266–2.342) 0.670
Nausea
 Yes 1.779 (0.843–3.756) 0.131 0.654 (0.190–2.260) 0.503
Palpitation
 Yes 1.995 (1.159–3.432) 0.013 2.014 (0.790–5.137) 0.143
Cold hands and feet
 Yes 3.098 (1.391–6.899) 0.006 1.676 (0.463–6.064) 0.431
Muscle pain
 Yes 2.971 (1.286–6.864) 0.011 5.199 (1.407–19.214) 0.013
Cramps
 Yes 1.918 (0.781–4.711) 0.155 3.073 (0.632–14.933) 0.164
Headache
 Yes 1.444 (0.860–2.424) 0.164 1.062 (0.454–2.488) 0.889
Anxiety
 Yes 1.909 (0.876–4.162) 0.104 0.906 (0.247–3.331) 0.882
Sleep poorly
 Yes 2.061 (1.054–4.029) 0.035 4.891 (1.578–15.160) 0.006
Skin rash
 Yes 3.171 (1.029–9.774) 0.044 2.132 (0.373–12.193) 0.395
Decreased sexual desire
 Yes 0.494 (0.229–1.065) 0.072 0.643 (0.203–2.043) 0.454
Number of adverse effects 1.140 (1.039–1.250) 0.005 0.776 (0.592–1.017) 0.066
Symptoms are caused by medications
 I don’t know 1   1  
 Yes 1.348 (0.669–2.714) 0.403 3.249 (1.248–8.456) 0.016
 No 2.141 (1.131–4.049) 0.019 1.720 (0.673–4.392) 0.257
Symptoms caused to change or stop medications 10.554 (4.169–26.717) 0.000 16.104 (4.164–62.290) 0.000
Regular exercise
 Yes 0.363 (0.209–0.632) 0.000 0.170 (0.072–0.402) 0.000