Skip to main content

Table 3 Meta-regression analyses (Dependent variable: natural log of relative risk for stroke)

From: Are the effects of blood pressure lowering treatment diminishing?: meta-regression analyses

  Model 1S (single) Model 2S (multiple)
Variable exp(b) 95% CI p-value exp(b) 95% CI p-value
Trial start year (per 10 years) 1.12 1.06–1.19 <  0.001 1.07 0.97–1.19 0.154
  Adjusted R2 = 50.5%    
Age (per 10 years) 1.02 0.93–1.13 0.642 1.00 0.89–1.12 0.973
  Adjusted R2 = −1.5%    
Sample size (per 1000 participants) 1.01 1.00–1.02 0.005 1.00 0.99–1.01 0.509
  Adjusted R2 = 30.9%    
Baseline SBP (per 10 mmHg) 0.94 0.91–0.98 0.003 1.03 0.97–1.09 0.399
  Adjusted R2 = 28.4%    
SBP difference (per 10 mmHg) 0.78 0.71–0.86 <  0.001 0.81 0.69–0.94 0.008
  Adjusted R2 = 60.5%    
Region (per category)
 Mixed region 1 (ref)    1 (ref)   
 North America 0.81 0.68–0.97 0.024 1.05 0.85–1.29 0.649
 Europe 0.81 0.69–0.94 0.008 0.97 0.81–1.17 0.782
 Asia 0.78 0.66–0.93 0.005 0.83 0.70–0.99 0.042
 Oceania 0.89 0.46–1.70 0.713    
  Adjusted R2 = 40.2%    
Adjusted R2   79.8%
K   67
  1. exp(b) the exponentiation of the b coefficient; ref. reference; CI confidence interval; K number of trials