Apolipoprotein A1 mimetic peptide ATI-5261 reverses arterial stiffness at late pregnancy and early postpartum in a COMT−/− mouse model of preeclampsia

Table 1 Maternal systolic blood pressure, proteinuria and pulse wave velocity

Parameters	COMT^−/− mice		C57BL/6 J mice
Parameters	Vehicle (n = 8)	ATI-5261 (n = 8)	Vehicle (n = 8)
Systolic blood pressure (mmHg)
Non-pregnant	117.4 ± 3.8	121.7 ± 2.5	118.2 ± 2.9
Gestational day 10.5	119.8 ± 2.8^a	122.5 ± 2.7^a	109.2 ± 2.5^b
Gestational day 18.5	128.4 ± 3.3^a	126.9 ± 2.9^a	107.8 ± 2.7^b
10 days postpartum	118.4 ± 2.1	116.3 ± 2.6	112.3 ± 2.3
Pulse wave velocity (m/s)
Gestational day 18.5	4.67 ± 0.22^a	4.02 ± 0.21^b	3.66 ± 0.15^b
10 days postpartum	4.86 ± 0.31^a	3.98 ± 0.18^b	3.88 ± 0.17^b

Data are presented as mean ± SEM. Groups were compared using one-way ANOVA with post-hoc analysis (Tukey’s procedure). Groups which do not share the same letter are significantly different from each other

ISSN: 2056-5909