Fig. 4

ABCA1, ABCG1 and SR-BI protein expressions. a and b Hepatic protein expressions of ABCA1, ABCG1 and SR-BI were significantly decreased in COMT^−/− mice at GD 18.5, compared to C57BL/6 J mice. Decreased hepatic ABCA1 expression was also observed at 10 days postpartum. ATI-5261 increased ABCA1 and ABCG1 expression in the liver at 10 days postpartum. c Placental protein expressions of ABCA1 and ABCG1 was reduced in COMT^−/− mice, compared to C57BL/6 J mice. ATI-5261 treatment significantly increased ABCA1 levels in the placenta of COMT^−/− mice. d Representative immunoblots of the corresponding proteins in the placenta with mouse RAW264.7 cell lysate included as positive control. Similar results were obtained when the experiment was repeated with lysates prepared from three batches of tissues. Data are presented as mean ± SEM. Groups (n = 8 in all groups) were compared using one-way ANOVA with post-hoc analysis (Tukey’s procedure). *, p < 0.05