Fig. 3

Serum ABCA1 and ABCG1 concentrations and cholesterol efflux capacity. a Serum ABCA1 concentrations were significantly decreased in vehicle treated COMT^−/− mice, compared with C57BL/6 J mice. ATI-5261 treatments increased serum ABCA1 concentrations in COMT^−/− mice at GD 18.5 and 10 days postpartum. b Serum ABCG1 concentrations were significantly decreased in vehicle treated or ATI-5261 treated COMT^−/− mice at 10 days postpartum. c and d Total cholesterol efflux capacity and ABCA1-dependent efflux were significantly increased in ATI-5261 treated COMT^−/− mice at GD 18.5 and 10 days postpartum compared to COMT^−/− mice. ABCA1-dependent efflux was decreased at 10 days postpartum in vehicle treated COMT^−/− mice compared with C57BL/6 J mice. Data are presented as mean ± SEM. Groups (n = 8 in all groups) were compared using one-way ANOVA with post-hoc analysis (Tukey’s procedure). *, p < 0.05