Fig. 2

Concentration-response curves for PE or MCh in isolated aortic rings. a and b Constriction of aortic rings in response to PE was increased in vehicle treated COMT^−/− mice compared to C57BL/6 J mice at GD 18.5 or 10 days postpartum. c and d Relaxation of aortic rings in response to MCh was decreased in vehicle treated COMT^−/− mice compared to C57BL/6 J mice at GD 18.5 or at 10 days postpartum. ATI-5261 treatment partially normalized vasoconstriction and vasorelaxation in COMT^−/− mice to that in C57BL/6 J mice. Data are presented as mean ± SEM. Vehicle treated COMT^−/− mice (n = 10 from 5 dams), ATI-5261 treated mice (n = 8 from 4 dams) and C57BL/6 J mice (n = 10 from 5 dams) were compared using one-way ANOVA with post-hoc analysis (Tukey’s procedure). *, p < 0.05 (when compared with C57BL/6 J mice)