Fig. 1

Maternal systolic blood pressure, proteinuria and pulse wave velocity. a Systolic blood pressure was significantly increased in vehicle treated or ATI-5261 treated COMT^−/− mice compared with C57BL/6 J mice at GD 10.5 and GD 18.5. ATI-5261 treatment had no effects on blood pressure at GD 18.5 or 10 days postpartum. The increased blood pressure observed in COMT^−/− mice returned to nonpregnant levels at 10 days after delivery. b Proteinuria, as assessed by albumin/creatinine ratio, was significantly increased in vehicle treated or ATI-5261 treated COMT^−/− mice compared with C57BL/6 J mice. Treatment with ATI-5261 had no effects on proteinuria. c PWV was significantly increased at GD 18.5 and 10 days postpartum in vehicle treated COMT^−/− mice compared with vehicle treated C57BL/6 J mice. ATI-5261 treatment significantly reduced PWV in COMT^−/− mice at GD 18.5 and 10 days postpartum. Data are presented as mean ± SEM. Groups (n = 8 in all groups) were compared using one-way ANOVA with post-hoc analysis (Tukey’s procedure). *, p < 0.05