|
Number of patients, n
|
747
|
727
| |
1474
|
|
Age, y
|
60.2 ± 3.4
|
70.8 ± 3.9
|
0.000
|
65.4 ± 6.5
|
|
Male, %
|
68.8%
|
72.8%
|
0.036
|
70.8%
|
|
History, %
|
|
MI
|
34.0%
|
35.2%
|
0.636
|
34.6%
|
|
Stable angina
|
19.6%
|
22.1%
|
0.095
|
20.8%
|
|
Unstable angina
|
10.7%
|
13.2%
|
0.128
|
11.9%
|
|
CABG
|
2.0%
|
2.8%
|
0.674
|
2.4%
|
|
PTCA/PCI
|
19.5%
|
22.7%
|
0.078
|
21.1%
|
|
Stroke/TIA
|
53.0%
|
49.5%
|
0.336
|
51.3%
|
|
Carotid endarterectomy
|
0
|
0
| |
0
|
|
Peripheral artery surgery
|
0.3%
|
0.7%
|
0.501
|
0.5%
|
|
Intermittent claudication
|
2.1%
|
2.6%
|
0.915
|
2.4%
|
|
Risk factors, %
|
|
Hypertension
|
74.4%
|
75.5%
|
0.944
|
75.0%
|
|
DM
|
32.8%
|
35.8%
|
0.373
|
34.3%
|
|
Current Smoking
|
15.1%
|
15.1%
|
0.741
|
15.1%
|
|
Former smoking
|
32.0%
|
33.6%
|
0.842
|
32.8%
|
|
Medications, %
|
|
ACE inhibitors
|
37.5%
|
34.7%
|
0.043
|
36.1%
|
|
Angiotensin II blockers
|
3.1%
|
4.4%
|
0.072
|
3.7%
|
|
β-blockers
|
37.9%
|
40.6%
|
0.271
|
39.2%
|
|
Diuretics
|
14.2%
|
19.3%
|
0.012
|
16.7%
|
|
Nitrates
|
43.8%
|
43.9%
|
0.897
|
43.8%
|
|
Diltiazem/verapamil
|
9.6%
|
8.9%
|
0.933
|
9.3%
|
|
Other calcium-channel blockers
|
46.3%
|
45.1%
|
0.313
|
45.7%
|
|
ASA
|
65.3%
|
74.8%
|
0.002
|
70.0%
|
|
Ticlopidine
|
2.3%
|
2.2%
|
0.766
|
2.2%
|
|
Clopidogrel
|
2.5%
|
4.1%
|
0.037
|
3.3%
|
|
Oral anticoagulants
|
4.0%
|
5.8%
|
0.114
|
4.9%
|
|
statins
|
26.1%
|
26.0%
|
0.812
|
26.1%
|
|
Insulin
|
6.3%
|
7.0%
|
0.829
|
6.6%
|
|
Oral hypoglycemic
|
24.6%
|
25.7%
|
0.617
|
25.2%
|
|
Estrogen(in females)
|
1.3%
|
1.5%
|
0.788
|
1.4%
|
|
Estrogen+progesterone(in females)
|
0
|
0.5%
|
0.282
|
0.2%
|
|
Physical exam
|
|
Heart rate (beats/min)
|
73
|
73
|
0.085
|
73
|
|
BP at run-in(mmHg)
|
140/80
|
141/80
|
0.261/0.761
|
141/80
|
|
BP at randomization(mmHg)
|
133/77
|
133/76
|
0.948/0.341
|
133/76
|
|
BMI
|
25.9
|
24.7
|
0.016
|
25.4
|
|
Waist-hip ratio
|
0.9
|
1.0
|
0.444
|
0.9
|
|
Laboratory results
|
|
Creatinine(μmol/L)
|
87.7
|
93.5
|
0.000
|
90.5
|
|
Potassium(mmol/L)
|
4.4
|
4.3
|
0.226
|
4.4
|
|
Total cholesterol(mmol/L)
|
5.3
|
5.1
|
0.044
|
5.2
|
|
HDL-cholesterol(mmol/L)
|
1.3
|
1.3
|
0.989
|
1.3
|
|
LDL-cholesterol(mmol/L)
|
2.8
|
2.8
|
0.949
|
2.8
|
|
Triglycerides(mmol/L)
|
1.8
|
1.7
|
0.067
|
1.8
|
