The utility of biomarker risk prediction score in patients with chronic heart failure

Clinical Hypertension

Table 4 Comparison of AUCs characterized biomarker models to standard model calculated for LFEV less 40 %. The results of ROC curve analysis

Models	AUC	95 % CI	P values
Standard Model: LVEF	0.646	0.612 – 0.661	-
NT-pro-BNP	0.683	0.644 – 0.703	0.045
Galectin-3	0.731	0.711 – 0.754	0.013
hs-CRP	0.656	0.634 – 0.687	0.068
Osteoprotegerin	0.722	0.707 – 0.739	0.012
sRANKL/osteoprotegerin ratio	0.734	0.723 – 0.752	0.001
CD14⁺CD309⁺Tie2 MPCs	0.785	0.755 – 0.794	0.001
CD31+/annexin V+ EMPs to CD14⁺CD309⁺ MPCs ratio	0.834	0.805 – 0.861	0.001

Abbreviations: AUC area under curve, ROC receive operation characteristic, LVEF left ventricular ejection fraction, BNP brain natriuretic peptide, hs-CRP high sensitive C-reactive protein, sRANKL serum receptor activator of nuclear factor-kappa B ligand, EMPs endothelial-derived apoptotic microparticles, MPCs mononuclear progenitor cells

ISSN: 2056-5909