| |
Control (n = 61)
|
Mild OSAS (n = 67)
|
Moderate OSAS (n = 61)
|
Severe OSAS (n = 101)
|
ANOVA p
|
|---|
|
Age, years
|
44.0 ± 15.4
|
48.2 ± 13.4
|
49.1 ± 11.8
|
51.4 ± 12.5*
|
0.003
|
|
Male, n (%)
|
33 (54.1)
|
39 (58.2)
|
41 (67.2)*
|
80 (79.2)*
|
<0.001
|
|
BMI, kg/m2
|
24.2 ± 4.43
|
24.7 ± 3.20
|
26.4 ± 3.58*,+
|
26.9 ± 3.41*,+
|
<0.001
|
|
SBP, mmHg
|
123.4 ± 13.7
|
123.5 ± 13.1
|
128.5 ± 13.6*
|
128.2 ± 12.4*
|
0.027
|
|
DBP, mmHg
|
78.4 ± 10.7
|
77.0 ± 8.9
|
80.8 ± 9.2
|
81.2 ± 9.9*
|
0.039
|
|
Heart rate, /min
|
72.6 ± 7.90
|
73.3 ± 10.3
|
76.3 ± 10.5
|
76.7 ± 9.15*
|
0.020
|
|
Hypertension, n (%)
|
5 (8.2)
|
13 (19.4)
|
18 (29.5)*
|
30 (29.7)*
|
0.005
|
|
Diabetes mellitus, n (%)
|
1 (1.6)
|
2 (3.0)
|
4 (6.6)
|
13 (12.9) *
|
0.048
|
|
Dyslipidemia, n (%)
|
2 (3.3)
|
2 (3.0)
|
3 (4.9)
|
3 (3.0)
|
0.917
|
|
Smoking, n (%)
|
6 (9.8)
|
14 (20.9)
|
12 (19.7)
|
18 (17.8)
|
0.123
|
|
Total cholesterol, mg/dl
|
170.0 ± 38.2
|
184.0 ± 34.6
|
190.6 ± 45.6
|
172.4 ± 46.9
|
0.161
|
|
TG, mg/dl
|
141.1 ± 84.8
|
151.2 ± 8.03
|
160.8 ± 89.1
|
176.1 ± 144.9
|
0.606
|
|
FBS, mg/dl
|
101.5 ± 17.2
|
92.8 ± 10.3
|
105.8 ± 21.7
|
111.6 ± 45.3
|
0.034
|
|
ESR, mm/hr
|
7.8 ± 11.6
|
17.9 ± 30.2
|
15.5 ± 15.3
|
14.0 ± 10.9
|
0.224
|
|
hs-CRP, mg/L
|
0.53 ± 1.32
|
1.14 ± 2.28
|
0.82 ± 1.38
|
1.12 ± 2.08
|
0.529
|
|
WBC, x106/L
|
6759 ± 1806
|
7283 ± 2031
|
7314 ± 2976
|
7724 ± 2051
|
0.103
|
|
Neutrophil, %
|
53.1 ± 11.2
|
59.1 ± 11.0
|
55.1 ± 13.8
|
60.5 ± 10.3*
|
0.001
|
|
Lymphocyte, %
|
36.1 ± 9.87
|
33.0 ± 12.8
|
30.0 ± 9.22
|
27.4 ± 8.35*
|
<0.001
|
|
Eosinophil, %
|
2.24 ± 1.66
|
3.01 ± 2.03
|
2.60 ± 1.99
|
2.90 ± 2.16
|
0.217
|
|
Monocyte, %
|
7.91 ± 2.54
|
7.44 ± 2.15
|
8.51 ± 5.96
|
7.35 ± 1.71
|
0.234
|
|
RBC, x109/L
|
4587 ± 423.9
|
4692 ± 377.2
|
4660 ± 282.4
|
4599 ± 378.1
|
0.286
|
|
Hemoglobin, g/dl
|
13.5 ± 1.5
|
14.0 ± 1.4
|
13.8 ± 1.6
|
14.4 ± 1.6*
|
0.004
|
|
Hematocrit, %
|
40.2 ± 4.4
|
41.2 ± 4.2
|
40.2 ± 6.6
|
42.5 ± 4.5*
|
0.010
|
|
RDW, %
|
13.5 ± 1.57
|
13.3 ± 1.25
|
13.5 ± 1.05
|
13.3 ± 0.76
|
0.735
|
|
Platelet, x109/L
|
216.7 ± 54.4
|
224.8 ± 56.0
|
231.3 ± 80.6
|
252.4 ± 66.8*
|
0.007
|
|
PLR
|
99.5 ± 42.1
|
113.8 ± 45.2
|
121.3 ± 62.9*
|
138.6 ± 59.9*
|
0.001
|
|
PDW, %
|
15.9 ± 1.12
|
16.3 ± 0.95
|
16.4 ± 0.99*
|
16.5 ± 0.82*
|
0.003
|
- All values are presented as means ± SD. BP, blood pressure; hs-CRP, high sensitivity C-reactive protein; OSAS: obstructive sleep apnea syndrome; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglyceride; FBS, fasting blood sugar; ESR, erythrocyte sedimentation rate; WBC, white blood cell; RBC, white blood cell; RDW, red cell distribution width; PLR, platelet lymphocyte ratio; PDW, platelet volume distribution width, *p < 0.05 vs. control group, +
p < 0.05 vs. mild OSAS group
