Table 1 Baseline patient characteristics

Age, years

44.0 ± 15.4

48.2 ± 13.4

49.1 ± 11.8

51.4 ± 12.5^*

0.003

Male, n (%)

33 (54.1)

39 (58.2)

41 (67.2)^*

80 (79.2)^*

<0.001

BMI, kg/m²

24.2 ± 4.43

24.7 ± 3.20

26.4 ± 3.58^*,+

26.9 ± 3.41^*,+

<0.001

SBP, mmHg

123.4 ± 13.7

123.5 ± 13.1

128.5 ± 13.6^*

128.2 ± 12.4^*

0.027

DBP, mmHg

78.4 ± 10.7

77.0 ± 8.9

80.8 ± 9.2

81.2 ± 9.9^*

0.039

Heart rate, /min

72.6 ± 7.90

73.3 ± 10.3

76.3 ± 10.5

76.7 ± 9.15^*

0.020

Hypertension, n (%)

5 (8.2)

13 (19.4)

18 (29.5)^*

30 (29.7)^*

0.005

Diabetes mellitus, n (%)

1 (1.6)

2 (3.0)

4 (6.6)

13 (12.9) ^*

0.048

Dyslipidemia, n (%)

2 (3.3)

2 (3.0)

3 (4.9)

3 (3.0)

0.917

Smoking, n (%)

6 (9.8)

14 (20.9)

12 (19.7)

18 (17.8)

0.123

Total cholesterol, mg/dl

170.0 ± 38.2

184.0 ± 34.6

190.6 ± 45.6

172.4 ± 46.9

0.161

TG, mg/dl

141.1 ± 84.8

151.2 ± 8.03

160.8 ± 89.1

176.1 ± 144.9

0.606

FBS, mg/dl

101.5 ± 17.2

92.8 ± 10.3

105.8 ± 21.7

111.6 ± 45.3

0.034

ESR, mm/hr

7.8 ± 11.6

17.9 ± 30.2

15.5 ± 15.3

14.0 ± 10.9

0.224

hs-CRP, mg/L

0.53 ± 1.32

1.14 ± 2.28

0.82 ± 1.38

1.12 ± 2.08

0.529

WBC, x10⁶/L

6759 ± 1806

7283 ± 2031

7314 ± 2976

7724 ± 2051

0.103

Neutrophil, %

53.1 ± 11.2

59.1 ± 11.0

55.1 ± 13.8

60.5 ± 10.3^*

0.001

Lymphocyte, %

36.1 ± 9.87

33.0 ± 12.8

30.0 ± 9.22

27.4 ± 8.35^*

<0.001

Eosinophil, %

2.24 ± 1.66

3.01 ± 2.03

2.60 ± 1.99

2.90 ± 2.16

0.217

Monocyte, %

7.91 ± 2.54

7.44 ± 2.15

8.51 ± 5.96

7.35 ± 1.71

0.234

RBC, x10⁹/L

4587 ± 423.9

4692 ± 377.2

4660 ± 282.4

4599 ± 378.1

0.286

Hemoglobin, g/dl

13.5 ± 1.5

14.0 ± 1.4

13.8 ± 1.6

14.4 ± 1.6^*

0.004

Hematocrit, %

40.2 ± 4.4

41.2 ± 4.2

40.2 ± 6.6

42.5 ± 4.5^*

0.010

RDW, %

13.5 ± 1.57

13.3 ± 1.25

13.5 ± 1.05

13.3 ± 0.76

0.735

Platelet, x10⁹/L

216.7 ± 54.4

224.8 ± 56.0

231.3 ± 80.6

252.4 ± 66.8^*

0.007

PLR

99.5 ± 42.1

113.8 ± 45.2

121.3 ± 62.9^*

138.6 ± 59.9^*

0.001

PDW, %

15.9 ± 1.12

16.3 ± 0.95

16.4 ± 0.99^*

16.5 ± 0.82^*

0.003