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Figure 3 | Clinical Hypertension

Figure 3

From: Angiotensin II induces endoplasmic reticulum stress in podocyte, which would be further augmented by PI3-kinase inhibition

Figure 3

LY294002, a PI3-kinase inhibitor, augments Ang II-induced ER stress. LY294002 further augments the upregulated phospho-PERK induced by low doses of Ang II (A). However, LY294002 does not affect phospho-eIF2α upregulated by Ang II (B). LY294002 further magnified upregulation of ATF4 induced by high doses of Ang II (C). Data on the densitometric analysis of each proteins/β-tubulin ratio are expressed as mean ± SD (n = 3). Control (100%); the value of no Ang II conditions. *P < 0.05 and **P < 0.01 versus control. # P < 0.05 versus the respective values without LY294002.

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