Table 1 Patients’ baseline characteristics according to d-dimer tertile
All patients (N = 4,127) | Tertile 1* (n = 1,376) | Tertile 2† (n = 1,376) | Tertile 3‡ (n = 1,375) | p value | |
|---|---|---|---|---|---|
Age | 65 (53–78) | 54 (45–62)§¶ | 68 (57–79)↑ | 76 (63–83) | < 0.001 |
Women | 1,891 (45.8) | 478 (34.7) | 683 (49.6) | 730 (53.1) | < 0.001 |
Medical history | |||||
Hypertension | 2,304 (57.1) | 596 (44.3) | 821 (61.0) | 887 (66.1) | < 0.001 |
Diabetes mellitus | 1,143 (28.7) | 242 (18.3) | 383 (28.7) | 518 (39.0) | < 0.001 |
Dyslipidemia | 453 (11.4) | 171 (12.9) | 164 (12.4) | 118 (8.9) | 0.002 |
Ischemic stroke | 379 (9.5) | 60 (4.5) | 125 (9.4) | 194 (14.7) | < 0.001 |
Hemorrhagic stroke | 129 (3.3) | 20 (1.5) | 39 (2.9) | 70 (5.3) | < 0.001 |
Coronary artery disease | 464 (11.7) | 103 (7.8) | 176 (13.3) | 185 (14.0) | < 0.001 |
Heart failure | 234 (5.9) | 18 (1.4) | 82 (6.2) | 134 (10.2) | < 0.001 |
Chronic kidney disease | 368 (9.3) | 19 (1.4) | 107 (8.1) | 242 (18.3) | < 0.001 |
End-stage renal disease | 182 (4.6) | 7 (0.5) | 57 (4.3) | 118 (8.9) | < 0.001 |
Social history | |||||
Cigarette smoking | 814 (27.1) | 366 (39.8) | 241 (24.0) | 207 (19.3) | < 0.001 |
Alcohol consumption | 1,078 (35.7) | 489 (53.0) | 341 (33.7) | 248 (22.8) | < 0.001 |
Triage vitals | |||||
SBP, mmHg | 184 (165–200) | 181 (163–196)§¶ | 186 (169–202) | 185 (165–203) | < 0.001 |
DBP, mmHg | 105 (100–113) | 106 (101–114)§¶ | 104 (97–113) | 103 (96–113) | < 0.001 |
Laboratory tests | |||||
d-dimer, ng/mL | 201 (85–504) | 63 (38–85)§¶ | 201 (152–268)↑ | 773 (504–1817) | < 0.001 |
eGFR, mL/min/1.73 m2 | 85 (61–99) | 98 (86–106)§¶ | 83 (63–97)↑ | 65 (34–86) | < 0.001 |
Hb, g/dL | 13.7 (12.2–15.0) | 14.7 (13.6, 15.7)§¶ | 13.7 (12.4–14.8)↑ | 12.5 (10.6–13.9) | < 0.001 |
BNP, pg/mL | 75 (26–282) | 23 (13–55)§¶ | 72 (32–232)↑ | 221 (80–770) | < 0.001 |
Troponin-I, ng/mL | 0.01 (0.01–0.03) | 0.01 (0.01–0.01)§¶ | 0.01 (0.01–0.03)↑ | 0.03 (0.01–0.06) | < 0.001 |
Urinalysis | |||||
Proteinuriaa | 931 (34.0) | 108 (13.5) | 277 (30.6) | 546 (52.8) | < 0.001 |
Chest radiography | |||||
Cardiomegaly | 576 (14.5) | 120 (9.1) | 207 (15.8) | 249 (18.8) | < 0.001 |
Electrocardiography | |||||
LVH | 448 (11.4) | 107 (8.2) | 164 (12.4) | 177 (13.5) | < 0.001 |
Myocardial ischemia | 355 (9.0) | 109 (8.4) | 105 (8.0) | 141 (10.8) | 0.025 |
Atrial fibrillation | 281 (7.1) | 46 (3.5) | 96 (7.3) | 139 (10.6) | < 0.001 |
Acute HMOD, n (%) | 1,900 (46.0) | 527 (38.3) | 635 (46.1) | 738 (53.7) | < 0.001 |